As far as the cameras are concerned, the Vivo X50e 5G on the rear packs a 48-megapixel primary camera with an f/1.79 aperture; a second 13-megapixel camera with an f/2.46 aperture; a third 8-megapixel camera with an f/2.2 aperture and a fourth 2-megapixel camera with an f/2.4 aperture. The rear camera setup has autofocus. It sports a 32-megapixel camera on the front for selfies, with an f/2.0 aperture.

The Vivo X50e 5G runs Funtouch OS 10 based on Android 10 and packs 128GB of inbuilt storage that can be expanded via microSD card. The Vivo X50e 5G is a dual-SIM (GSM and GSM) smartphone that accepts Nano-SIM and Nano-SIM cards. The Vivo X50e 5G measures 162.05 x 74.97 x 8.88mm (height x width x thickness) and weighs 200.40 grams. It was launched in Black and White colours.

Connectivity options on the Vivo X50e 5G include Wi-Fi 802.11 a/b/g/n/ac, GPS, Bluetooth v5.10, NFC, USB OTG, USB Type-C, FM radio, 3G, and 4G. Sensors on the phone include accelerometer, ambient light sensor, compass/ magnetometer, gyroscope, proximity sensor, and in-display fingerprint sensor.