Oppo F21 Pro mobile was launched on 12th April 2022. The phone comes with a 90 Hz refresh rate 6.43-inch display offering a resolution of 1080x2400 pixels (FHD) at a pixel density of 409 pixels per inch (ppi) and an aspect ratio of 20:9. The display sports Gorilla Glass for protection. Oppo F21 Pro is powered by an octa-core Qualcomm Snapdragon 680 processor. It comes with 8GB of RAM. The Oppo F21 Pro runs Android 12 and is powered by a 4500mAh battery.

As far as the cameras are concerned, the Oppo F21 Pro on the rear packs a triple camera setup featuring a 64-megapixel (f/1.7) primary camera; a 2-megapixel (f/3.3) camera, and a 2-megapixel (f/2.4) camera. The rear camera setup has autofocus. It has a single front camera setup for selfies, featuring a 32-megapixel sensor with an f/2.4 aperture.

The Oppo F21 Pro runs ColorOS 12.1 is based on Android 12 and packs 128GB of inbuilt storage. The Oppo F21 Pro is a dual-SIM (GSM and GSM) mobile that accepts Nano-SIM and Nano-SIM cards. The Oppo F21 Pro measures 159.90 x 73.20 x 7.49mm (height x width x thickness) and weighs 175.00 grams. It was launched in Cosmic Black and Sunset Orange colours.

Connectivity options on the Oppo F21 Pro include Wi-Fi 802.11 a/b/g/n/ac, GPS, Bluetooth v5.10, USB Type-C, 3G, and 4G (with support for Band 40 used by some LTE networks in India). Sensors on the phone include accelerometer, ambient light sensor, compass/ magnetometer, gyroscope, proximity sensor, and in-display fingerprint sensor.